Polynucleotides - what are they?
As my medical aesthetics practice continues to evolve, I remain committed to introducing treatments that are grounded in science, regenerative medicine, and anatomical precision. I am therefore pleased to share that I will be completing advanced training in polynucleotides this week by Derma Focus, Mastelli, expanding on the regenerative treatment options available to my patients.
🧬 What Are Polynucleotides?🧬
Polynucleotides are highly purified DNA-derived fragments used in aesthetic medicine as biostimulatory injectables. Unlike traditional dermal fillers, they do not provide volumisation. Instead, they act at a cellular level to promote tissue repair, improve dermal quality, and stimulate collagen synthesis.
Their mechanism of action is based on regenerative principles. Once injected into the dermis, polynucleotides:
🧬 Stimulate fibroblast activity
🧬 Enhance type I collagen production
🧬 Improve extracellular matrix integrity
🧬 Increase tissue hydration through water-binding capacity
🧬 Support angiogenesis and microcirculation
🧬 Exert anti-inflammatory and antioxidant effects
The result is progressive improvement in skin thickness, elasticity, and overall structural integrity.
Clinical Applications
Polynucleotides are particularly beneficial in areas where dermal quality is compromised or delicate, including:
⭐️ Periorbital (under-eye) rejuvenation
⭐️ Atrophic or sun-damaged skin
⭐️ Acne scarring
⭐️ Fine lines and skin laxity
⭐️ Neck and décolletage rejuvenation
They are especially suited to patients seeking regenerative improvement rather than structural augmentation.
A Regenerative Approach to Aesthetics
With a background in ENT surgery, I place significant emphasis on detailed anatomical understanding, vascular safety, and tissue plane accuracy. Regenerative injectables such as polynucleotides align closely with my approach to aesthetics and medicine in general, prioritising long-term health and physiological enhancement over excessive volumisation.
Mastelli Range of Polynucleotides
As I complete my Derma Focus polynucleotide training, I look forward to integrating polynucleotide therapy (Plinest, Plinest Eye & Newest) into practice, offering patients an evidence-based, biologically driven approach to skin rejuvenation.