A healthcare professional administering a treatment to a patient's knee with a syringe. The professional wears gloves and a dark uniform, focusing on the procedure.

Polynucleotides

Three skincare product boxes labeled Plinest, Newest, and Plinest Eye, with colorful designs, arranged side by side on a white background.

Plinest Polynucleotides by DermaFocus are an advanced, regenerative injectable treatment designed to improve skin quality and stimulate repair at a cellular level. Using highly purified polynucleotides, Plinest works by activating fibroblasts to boost collagen and elastin production, enhance hydration, and support tissue regeneration. This helps improve skin texture, elasticity, and overall radiance while softening fine lines. The treatment is commonly chosen for delicate areas such as the under-eyes, face, neck, and hands, and is ideal for patients seeking natural, progressive rejuvenation rather than added volume. We also use the new treatment Newest which contains additional hyaluronic acid, targeted at mature skin requiring extra hydration. Results develop gradually as collagen production increases, with a course of treatments recommended for optimal, longer-lasting improvement.

Procedure time
30-60mins

Duration of effects
6-9 months

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Downtime
Minimal

FAQs

Download Information Leaflet - Polynucleotides

  • Plinest Polynucleotides are highly purified DNA fragments that act as biostimulatory agents within the skin. Newest contains additional Hyaluronic Acid. Once injected into the dermis, they stimulate fibroblast activity, promoting the synthesis of collagen and elastin while supporting extracellular matrix remodelling.

    They also exert a strong hydrophilic effect (water-attracting), improving tissue hydration, and have antioxidant properties that help neutralise free radicals (small molecules that can cause stress response within the body) and reduce inflammation.

    The result is:

    ✨Improved skin density

    ✨Improved elasticity

    ✨Improved structural integrity

    ✨Gradual regeneration

    ✨Enhanced overall skin quality over time

    The future of skincare is regenerative aesthetics.

  • The rejuvenating effects of polynucleotides develop gradually as collagen and elastin production increases, with visible improvements typically appearing within 2–4 weeks after treatment. Results continue to improve over the following weeks and can last approximately 6–9 months, depending on the individual and area treated.

    For optimal, long-term skin health and sustained vitality, maintenance treatments are generally recommended every 6 months.

  • For optimal results, a course of 2–3 treatments spaced 3–4 weeks apart is typically recommended. This allows collagen and elastin production to build progressively, enhancing skin quality and texture.

    After the initial course, maintenance sessions every 6 months help sustain long-term improvement and vitality. Individual plans may vary based on your skin concerns and goals.

  • Plinest polynucleotide treatments are generally well-tolerated and not considered highly painful—but some mild discomfort is common. Most patients describe the sensation during injections as a light pinch, pressure, or brief stinging rather than sharp pain.

    To enhance comfort, topical numbing cream is usually applied before the procedure, and at ENT Aesthetics we use very fine needles to minimise sensation.

  • Polynucleotide treatments are generally very safe when performed by a medically trained practitioner.

    The most common side effects are mild and temporary, including redness, slight swelling, small raised bumps, tenderness, or bruising at the injection sites. These typically settle within a few hours to a few days.

    More significant complications are rare.

    A full consultation is always carried out beforehand to ensure suitability and minimise risk.